About transamination, Vitamin B6 and Pyridoxal Phosphate

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The Biochemistry Questions Site

Answer to Biochemistry Question AM-03

 

TRANSAMINATION:

 

         Interchange of the functional groups between an a-keto acid and one amino acid

 

         ENZYMES THAT CATALYZE THESE REACTIONS:

         Aminotransferases or transaminases

 

                                                       transamination

 

         REQUIRED COFACTOR

         Pyridoxal Phosphate

 

 

Pyridoxal phosphate

 

                                                             Pyridoxal phosphate structure

 

Pyridoxal Phosphate is the active form of Vitamin B-6.  This vitamin has three active forms: pyridoxal, pyridoxine (or piridoxol) and  pyridoxamine. (sometimes pyridoxine is used as synonym of Vitamin B6)

 

Besides Transamination, Pyridoxal phosphate participates in several other reactions as cofactor, including:

 

         Glycogenolysis (cofactor of glycogen phosphorylase but participates with the Phosphate group)

         Hem synthesis

 

         METABOLISM OF AMINO ACIDS

                        Decarboxylation

Racemization

                        Non-oxidative deamination

                       

Deficit of Vitamin B6:

 

 

         Deficit alone is uncommon. It usually appears associated…

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